Institute Professor at MIT., The McGovern Institute of Brain Research. Her research is focused on how the regions of the forebrain that influence movement, mood and motivation — the basal ganglia and neural pathways interconnecting the basal ganglia with the cerebral cortex — operate in normal and abnormal conditions. Central to many of these studies is work on brain mechanisms underlying learning and how motivation and emotions are linked to the development of action plans, habits, and repetitive behaviors. The research of her laboratory has a special focus on understanding how such mechanisms can become dysfunctional in neurologic disorders such and Parkinson’s disease and Huntington’s disease, and in neuropsychiatric disorders including obsessive-compulsive disorder, autism, and related human conditions. To approach these issues, Dr. Graybiel and her group apply combinations of methods ranging from multi-electrode recordings from neurons in the brain to genetic engineering.